Solid Phase Peptide Synthesis

In the late 1980s, Europe and America took the lead in the industrialized production of polypeptide raw materials based on solid-phase synthesis technology.

At present, the raw excipients used in the production of solid phase peptide synthesis raw materials are mostly produced in China. The whole East Asia region is also the main region of raw excipients supply for solid-phase synthetic polypeptide raw materials in the world. When choosing raw materials and accessories, we should consider the quality, price, process matching and other aspects. The extreme value of a single parameter is often confirmed to be not the optimal choice.

Polypeptide synthesis on a solid support, a concept of originality pioneered by Robert Bruce M errifield in 1963, is a major breakthrough in peptide chemistry.

The Boc/Bzl (tert-butoxycarbonyl/ /benzyl) method is a classical peptide solid phase synthesis method in which Boc is used as a temporary protecting group in combination with a benzylic semi-permanent side chain protecting group.

The Fmoc method is a new method for solid phase synthesis of peptides developed by Carpino and Hart based on the Boc method.